Medenine (Arabic: مدنين Madanīyīn) is the major town in southeastern Tunisia, 77 kilometres south of the port of Gabès and the Island of Djerba, on the main route to Libya. It is the capital of Medenine Governorate. In pre-colonial times, Medenine was already the most important trading centre in the south, attracting merchants from all over North Africa and even from Bornu, to the south of the Sahara. The Ksar housed the central granaries of the various nomadic Berber tribes of the region.
The Amphitheatre of El Jem, Tunisia was built in the 3rd century in the ancient Roman town of Thysdrus. It is the largest Roman amphitheatre in North Africa - holding between 27,000 and 30,000 people making it possibly the third or fourth biggest in the Empire after the Colosseum (or Coliseum) in Rome and that at Capua.. - was also used for filming some of the scenes the film Gladiator.