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Researchers from the Beijing Forestry University have developed a clustering mixture model to discover distinct groups of genes expressed du...

Researchers from the Beijing Forestry University have developed a clustering mixture model to discover distinct groups of genes expressed du...

A regression-based differential expression detection algorithm for studies with ultra-low sample size - Global gene expression analysis using microarrays and, more recently, RNA-seq, has allowed investigators to understand biological processes at a system level. However, the identification of differentially expressed genes in experiments with small sample size, high dimensionality, and high variance remains challenging, limiting the usability of these tens of thousands of publicly…

A regression-based differential expression detection algorithm for studies with ultra-low sample size - Global gene expression analysis using microarrays and, more recently, RNA-seq, has allowed investigators to understand biological processes at a system level. However, the identification of differentially expressed genes in experiments with small sample size, high dimensionality, and high variance remains challenging, limiting the usability of these tens of thousands of publicly…

Normalization and Differential Expression in RNA-Seq - Sandrine Dudoit, talks to the Toronto Bioinformatics User Group about Normalization and Differential Expression in RNA-Seq. Find out more about TorBUG at http://www.torbug.org.

Normalization and Differential Expression in RNA-Seq - Sandrine Dudoit, talks to the Toronto Bioinformatics User Group about Normalization and Differential Expression in RNA-Seq. Find out more about TorBUG at http://www.torbug.org.

Tailor – a computational framework for detecting non-templated tailing of small silencing RNAs - Small silencing RNAs, including microRNAs, endogenous small interfering RNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs), have been shown to play important roles in fine-tuning gene expression, defending virus and controlling transposons. Loss of small silencing RNAs or components in their pathways often leads to severe developmental defects, including lethality and sterility. Recently…

Tailor – a computational framework for detecting non-templated tailing of small silencing RNAs - Small silencing RNAs, including microRNAs, endogenous small interfering RNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs), have been shown to play important roles in fine-tuning gene expression, defending virus and controlling transposons. Loss of small silencing RNAs or components in their pathways often leads to severe developmental defects, including lethality and sterility. Recently…

This study conducted by the DNA Sequencing Research Group (DSRG) focuses on the evaluation of amplification kits for RNA-Seq. Four commercia...

This study conducted by the DNA Sequencing Research Group (DSRG) focuses on the evaluation of amplification kits for RNA-Seq. Four commercia...

Removing technical noise from single cell RNA-Seq data - Single-cell RNA-seq is a promising technology with broad applications and discerning biological noise from technical noise is critical for correctly interpreting the data (Jaitin, et al., 2014). Recently, statistical methods are developed to model the technical noise from spike-in ERCC molecules, whose concentrations are presumably same across...

Removing technical noise from single cell RNA-Seq data - Single-cell RNA-seq is a promising technology with broad applications and discerning biological noise from technical noise is critical for correctly interpreting the data (Jaitin, et al., 2014). Recently, statistical methods are developed to model the technical noise from spike-in ERCC molecules, whose concentrations are presumably same across...

RNA-Seq Assembly – Fundamental Limits, Algorithms and Software | RNA-Seq Blog

RNA-Seq Assembly – Fundamental Limits, Algorithms and Software | RNA-Seq Blog

To get novel insights into the mechanisms of prostate adenocarcinoma by  leveraging next generation sequencing (NGS) data, particularly huma...

To get novel insights into the mechanisms of prostate adenocarcinoma by leveraging next generation sequencing (NGS) data, particularly huma...

Computational analyses of small RNA sequencing data: possibilities and pitfalls | RNA-Seq Blog

Computational analyses of small RNA sequencing data: possibilities and pitfalls | RNA-Seq Blog

RNA-Seq is a powerful tool used to obtain in-depth information on expression profiling, gene annotation, and transcript discovery. With the ...

RNA-Seq is a powerful tool used to obtain in-depth information on expression profiling, gene annotation, and transcript discovery. With the ...

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