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Reconstitution with fingolimod is not always quick   Ghadiri M Fitz-Gerald L Rezk A Li R Nyirenda M Haegert D Giacomini PS Bar-Or A Antel J.Reconstitution of the peripheral immune repertoire following withdrawal of fingolimod Mult Scler. 2017;23(9):1225-1232. doi: 10.1177/1352458517713147. BACKGROUND:Following fingolimod cessation immune reconstitution or lack thereof may have consequences for disease rebound or safety of commencing alternative therapies. OBJECTIVE:To examine the degree and…

Reconstitution with fingolimod is not always quick Ghadiri M Fitz-Gerald L Rezk A Li R Nyirenda M Haegert D Giacomini PS Bar-Or A Antel J.Reconstitution of the peripheral immune repertoire following withdrawal of fingolimod Mult Scler. 2017;23(9):1225-1232. doi: 10.1177/1352458517713147. BACKGROUND:Following fingolimod cessation immune reconstitution or lack thereof may have consequences for disease rebound or safety of commencing alternative therapies. OBJECTIVE:To examine the degree and…

Childhood MS shows us that Memory B cells are Important in MS     Schwarz A Balint B Korporal-Kuhnke M Jarius S von Engelhardt K Fürwentsches A Bussmann C Ebinger F Wildemann B Haas J.B-cell populations discriminate between pediatric- and adult-onsetmultiple sclerosis.Neurol Neuroimmunol Neuroinflamm. 2016;4(1):e309  OBJECTIVE:  METHODS:  RESULTS:  CONCLUSIONS:  This provides further evidence for a role of B cell memory in MS. The authors are not looking for anything other than B cells and…

Childhood MS shows us that Memory B cells are Important in MS

#NeuroSpeak & #ClinicSpeak: treating PML-related IRIS   A new treatment for PML-related IRIS based on hard science and anecdote #NeuroSpeak #ClinicSpeak #MSBlog Substituting one disease for another. A large number of you argue that by treating MS a disabling disease with immunosuppressive therapies we simply create another ticking time bomb and swap one disease MS for another disease immunosuppression. The difference between these two diseases is that MS-related disability is in general…

#NeuroSpeak & #ClinicSpeak: treating PML-related IRIS A new treatment for PML-related IRIS based on hard science and anecdote #NeuroSpeak #ClinicSpeak #MSBlog Substituting one disease for another. A large number of you argue that by treating MS a disabling disease with immunosuppressive therapies we simply create another ticking time bomb and swap one disease MS for another disease immunosuppression. The difference between these two diseases is that MS-related disability is in general…

MS and EBV    If EBV is the driver of MS then there must surely be evidence that something related to EBV that associates with disease activity.  Does the Black Swan get it?  Gieß RM Pfuhl C Behrens JR Rasche L Freitag E Khalighy N Otto C Wuerfel J Brandt AU Hofmann J Eberspächer B Bellmann-Strobl J Paul F Ruprecht K.Epstein-Barr virus antibodies in serum and DNA load in saliva are not associated with radiological or clinical disease activity in patients with earlymultiple sclerosis.PLoS…

MS and EBV If EBV is the driver of MS then there must surely be evidence that something related to EBV that associates with disease activity. Does the Black Swan get it? Gieß RM Pfuhl C Behrens JR Rasche L Freitag E Khalighy N Otto C Wuerfel J Brandt AU Hofmann J Eberspächer B Bellmann-Strobl J Paul F Ruprecht K.Epstein-Barr virus antibodies in serum and DNA load in saliva are not associated with radiological or clinical disease activity in patients with earlymultiple sclerosis.PLoS…

Probiotics - Gut Microbiota for Health

Probiotics - Gut Microbiota for Health

Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses.   Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses.Paroni M Maltese V De Simone M Ranzani V Larghi P Fenoglio C Pietroboni AM De Riz MA Crosti MC Maglie S Moro M Caprioli F Rossi R Rossetti G…

Recognition of viral and self-antigens by and central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses.

Translation of the Multiple Sclerosis Quality of Life-54: Brazilian Version

Lifestyle: Top 10 Countries With the Greatest Quality of Life

An alternative MRI - MRS and PET imaging in MS  Mult Scler. 2016 Nov 30. pii: 1352458516681504. [Epub ahead of print] Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.  Datta G Violante IR Scott G Zimmerman K Santos-Ribeiro A Rabiner EA Gunn RN Malik O Ciccarelli O Nicholas R Matthews PM. Abstract BACKGROUND: Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by…

An alternative MRI - MRS and PET imaging in MS Mult Scler. 2016 Nov 30. pii: 1352458516681504. [Epub ahead of print] Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis. Datta G Violante IR Scott G Zimmerman K Santos-Ribeiro A Rabiner EA Gunn RN Malik O Ciccarelli O Nicholas R Matthews PM. Abstract BACKGROUND: Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by…

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