Snow’s chloroform inhaler, 1858 was designed by John Snow (1813-58). He was the first specialist anaesthetist in Britain and he administered anesthesia to Queen Victoria during the birth of her son Leopold in 1853. He is considered to be one of the fathers of epidemiology, because of his work in tracing the source of a cholera outbreak in Soho, England, in 1854.
The first public demonstration of surgical anesthesia, at the Massachusetts General Hospital, October 16, 1846. Various anesthetics, from alcohol to opium, were used through history, but it was not until 1846 that a successful operation was demonstrated to the public and an account published. Administering ether gas through the patient's mouth, was American dentist William T.G. Morton.(1819-1868). Some observers left the theater in disgust, believing the demonstration to be a sham.