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DNA packed into chromatin - histone and nonhistone proteins; repeating unit is nucleosome  - DNA wrapped around core of 8 histones. Chromatin maintains structure. Acetylation of histones occurs at ends - plays key role, controlled by histone acetyl transferse (HAT and HDAC). Must become physically accessible/uncoiled for translation - HDAC results in tight coiling. In some cancer cells, an overrecruiment of HDAC resulting in hyper-acetylation and closed chromatin structure.

DNA packed into chromatin - histone and nonhistone proteins; repeating unit is nucleosome - DNA wrapped around core of 8 histones. Chromatin maintains structure. Acetylation of histones occurs at ends - plays key role, controlled by histone acetyl transferse (HAT and HDAC). Must become physically accessible/uncoiled for translation - HDAC results in tight coiling. In some cancer cells, an overrecruiment of HDAC resulting in hyper-acetylation and closed chromatin structure.

A stepwise epigenetic process controls immunoglobulin allelic exclusion  (Credit: Yehudit Bergman and Howard Cedar, Nat Rev Immunol) #NPG #sub

A stepwise epigenetic process controls immunoglobulin allelic exclusion (Credit: Yehudit Bergman and Howard Cedar, Nat Rev Immunol) #NPG #sub

Why are people in industrialized countries obese? Both mice and people have a gene called agouti. If it is turned on in a mouse, the mouse turns yellow and is obese and prone to diabetes and cancer. When pregnant yellow agouti mothers were fed BPA ( which we get from water bottles and tin cans) more yellow, unhealthy babies were born than normal... [Excellent Article on Epigenetics and Diet]

Why are people in industrialized countries obese? Both mice and people have a gene called agouti. If it is turned on in a mouse, the mouse turns yellow and is obese and prone to diabetes and cancer. When pregnant yellow agouti mothers were fed BPA ( which we get from water bottles and tin cans) more yellow, unhealthy babies were born than normal... [Excellent Article on Epigenetics and Diet]

Do you have a soul?

Do you have a soul?

How dare you? *puts hands on hips* Even without this admittedly adorable cat I am FULL OF SOUL. Just FEEL all that soul. I emanate soul. *waves arms to cement point*

View Virtual Tour at "Genome: Unlocking Life's Code" exhibition at Smithsonian National Museum Natural History.

View Virtual Tour at "Genome: Unlocking Life's Code" exhibition at Smithsonian National Museum Natural History.

Understanding Epigenetics and Epigenetics and the Environment - #blueprintsofhope.com

Understanding Epigenetics and Epigenetics and the Environment - #blueprintsofhope.com

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