Beyond This Horizon (Heinlein. R.A. 1942) - A novel where mankind now lives in a state of genetic perfection through the use of genetic engineering. I have chosen this as it focuses on the use of genetic engneering and the detriments of perfection.
Farnham's Freehold (1964) is a science fiction novel set in the near future by Robert A. Heinlein. Farnham's Freehold is a post-apocalyptic tale, as the setup for the story is a direct hit by a nuclear weapon, which sends a fallout shelter containing a man, his wife, son, daughter, daughter's friend, and black domestic servant into the future. The book is popular with survivalist groups.