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At venlafaxine dosages of <150 mg/d, an immediate switch to another SNRI of equiva­lent dosage generally is well-tolerated. For higher dosages, a gradual cross-taper is advised. Most patients tolerate a venlafaxine dosage reduction by 75 mg/d, at 1-week intervals.


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Some patients experience brain shivers during Effexor withdrawal, an electric shock sensation that isn't dangerous but can be frightening.


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