Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2

Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2

Adherens and tight junctions: Structure, function and connections to the actin cytoskeletonFull-size image (10 K)

Adherens and tight junctions: Structure, function and connections to the actin cytoskeletonFull-size image (10 K)

Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor sign...

Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor sign...

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

Tight junctions (Zonula occludens)

Tight junctions (Zonula occludens)

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

GCC agonists as ulcerative colitis therapeutics.Notes: In ulcerative colitis, abnormal immune responses and colonic inflammation reflect inappropriate luminal antigen exposure for disruption of the mucosal barrier integrity (left panel). Pathogenetic mechanisms underlying loss of intestinal barrier function, in turn, include mutually reinforcing processes of cell lineage imbalance, defective mucus layer, tight junction disassembly and epithelial cell hyper-permeability (left panel)…

GCC agonists as ulcerative colitis therapeutics.Notes: In ulcerative colitis, abnormal immune responses and colonic inflammation reflect inappropriate luminal antigen exposure for disruption of the mucosal barrier integrity (left panel). Pathogenetic mechanisms underlying loss of intestinal barrier function, in turn, include mutually reinforcing processes of cell lineage imbalance, defective mucus layer, tight junction disassembly and epithelial cell hyper-permeability (left panel)…

Leaky Gut is Benchmark of Autoimmunity.  Study: “Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease.” 7 food additives:  These additives are; sugar, salt, emulsifiers, organic solvents, gluten, microbial transglutaminase, and nanoparticles.

Leaky Gut is Benchmark of Autoimmunity. Study: “Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease.” 7 food additives: These additives are; sugar, salt, emulsifiers, organic solvents, gluten, microbial transglutaminase, and nanoparticles.

Zonulin… "gliadin and its petides interact with the intestinal epithelium increasing intestinal permeability through the release of zonulin that, in turn, enables paracellular translocation of gliadin and it's subsequent interactions with macrophages within the intestinal submucosa."

Zonulin… "gliadin and its petides interact with the intestinal epithelium increasing intestinal permeability through the release of zonulin that, in turn, enables paracellular translocation of gliadin and it's subsequent interactions with macrophages within the intestinal submucosa."

"Tight Junctions, Intestinal Permeability, and Autoimmunity Celiac Disease and Type 1 Diabetes Paradigms," from the Annals of the New York Academy of Sciences

"Tight Junctions, Intestinal Permeability, and Autoimmunity Celiac Disease and Type 1 Diabetes Paradigms," from the Annals of the New York Academy of Sciences

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