August 27, 2013: Sideroblastic anemia or sideroachrestic anemia is a disease in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). It may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome, which can evolve into hematological malignancies (especially acute myelogenous leukemia).

August 27, 2013: Sideroblastic anemia or sideroachrestic anemia is a disease in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). It may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome, which can evolve into hematological malignancies (especially acute myelogenous leukemia).

Ringed sideroblast sideroblastic anemia

Ringed sideroblast sideroblastic anemia

Pappenheimer bodies = IRON granules in mitochondria = sideroblastic anemia and asplenism.

Pappenheimer bodies = IRON granules in mitochondria = sideroblastic anemia and asplenism.

Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM.  All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM. All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

Pappenheimer (e.g. in sideroblastic anemia) vs. Howell-jolly body (e.g. in sickle cell)

Pappenheimer (e.g. in sideroblastic anemia) vs. Howell-jolly body (e.g. in sickle cell)

Ring Sideroblasts in Sideroblastic Anemia. BM.

Ring Sideroblasts in Sideroblastic Anemia. BM.

Coenzyme Q , sideroblastic anemia and mitochondrial myopathy Review Notes Dr. Mohammed AlKhateeb "Coenzyme Q10, also known as ubiquinone,ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10...

Coenzyme Q , sideroblastic anemia and mitochondrial myopathy Review Notes Dr. Mohammed AlKhateeb "Coenzyme Q10, also known as ubiquinone,ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10...

sideroblastic anemia = ringed sideroblasts in BM; low MCHC, bimodal RDW; iron indices all high (serum iron, transferrin, ferritin)

sideroblastic anemia = ringed sideroblasts in BM; low MCHC, bimodal RDW; iron indices all high (serum iron, transferrin, ferritin)

Ringed Sideroblasts Characteristic of Sideroblastic Anemia

Ringed Sideroblasts Characteristic of Sideroblastic Anemia

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