Fat Loss Vs. Weight Loss Lose to Win: How To Lose Fat Instead of Weight. To lose weight: means you want to decrease the number on the scale, which weighs your body, which is made up of muscles, organs, fat and bones. To lose weight you simply have to restrict calories. To lose fat: means you want to decrease the amount of fat that is in your body, it is responsible for increasing the size. To lose fat, you have to control your hormones.