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AMP-activated Protein Kinase

Researchers identify cellular regulator of glucose transport in the human body.

Researchers from UT Southwestern have gleaned a key cellular mechanism of how the body adjusts glucose levels, an important process that when abnormal can promote diabetes, cancer, and rare genetic diseases. The researchers determined that an enzyme called Protein Kinase C (PKC) can regulate whether more or less glucose should be transported into cells, serving as a kind of thermostat to ensure that proper levels are maintained. The team state that precisely controlling glucose transport is…

Ponatinib (also known as AP24534) is a type II protein kinase inhibitor and an experimental drug candidate for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). It has been found effective against ABL kinase with its gatekeeper reside mutated from tyrosine to isoleucine.

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Methods in Enzymology Vol.548 Protein Kinase Inhibitors in Research and Medicine…

Glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H+/K+-ATPase activity. Inhibits the hepatic carcinogenic effec ts of aflatoxin B1. Antioxidant and anti-inflammatory. Tocris Bioscience 5245 Feedback Form

PS48 - CAS 1180676-32-7 PS48 is an allosteric small molecule that activates phosphoinositide-dependent protein kinase 1 (PDK1) by binding exclusively to the HM/PIF binding pocket rather than the ATP-binding site.

Biosyn (biosyn.com) using similar high-precision printing technology, peptides or proteins can be spotted on membrane-coated glass slides. Using different detection technologies, recombinant proteins/antibodies, cell lysate or serum samples can be quantitatively assayed. Protein #Microarray technology has a wide range of applications in protein-protein interaction studies, including antigen-antibody recognitions, kinase-substrate bindings, pathway analysis, biomarker screenings, and much…

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PLOS Biology: Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life...

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Ibrutinib, a.k.a. PCI-32765, is an experimental cancer drug that targets Bruton's tyrosine kinase (Btk).

Methods in Enzymology Vol.457 Mitochondrial Function Part B: Mitochondrial…