In a first, SAHMRI and University of Adelaide scientists have found a connection between the levels of a particular protein, called P-glycoprotein, in the body and a patient’s response to therapy when they use the popular drug Glivec to treat chronic myeloid leukaemia.

In a first, SAHMRI and University of Adelaide scientists have found a connection between the levels of a particular protein, called P-glycoprotein, in the body and a patient’s response to therapy when they use the popular drug Glivec to treat chronic myeloid leukaemia.

Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Antibodies and their antigen. Computer model showing the molecular structure of two anti-P-glycoprotein antibodies (upper left and right) and the P-glycoprotein (blue) to which they respond. These antibodies will bind to the glycoprotein, preventing it from functioning.  ©Laguna Design/Science Source

SP8395: Antibodies and their antigen

Antibodies and their antigen. Computer model showing the molecular structure of two anti-P-glycoprotein antibodies (upper left and right) and the P-glycoprotein (blue) to which they respond. These antibodies will bind to the glycoprotein, preventing it from functioning. ©Laguna Design/Science Source

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

<p>Colon spasms can really ruin your day or days depending upon the length of time they last. They can disrupt you at any suitable times, might be you remain in the crucial business conference, exercising in the health club, or browsing some... #Diarrhea #Digestion #AbdominalPain #IrritableBowelSyndrome #Dehydration #LargeIntestine #Gastroenteritis #Bacteria #Defecation #Enzyme #Nausea #Cirrhosis #Kidney #Diverticulitis #Diverticulosis #Antibiotics #Constipation #Electrolyte #CoeliacDisease…

Colon Spasms Symptoms

<p>Colon spasms can really ruin your day or days depending upon the length of time they last. They can disrupt you at any suitable times, might be you remain in the crucial business conference, exercising in the health club, or browsing some... #Diarrhea #Digestion #AbdominalPain #IrritableBowelSyndrome #Dehydration #LargeIntestine #Gastroenteritis #Bacteria #Defecation #Enzyme #Nausea #Cirrhosis #Kidney #Diverticulitis #Diverticulosis #Antibiotics #Constipation #Electrolyte #CoeliacDisease…

ABC Transporter Pgp-1 ( P-glycoprotein-1) - YouTube

ABC Transporter Pgp-1 ( P-glycoprotein-1) - YouTube

Piperine is an alkaloid extracted from black pepper (P. nigrum) and long pepper (P. longum). Previous studies have shown that piperine has anti-inflammatory, antiarthritic and anti-depressant effects [8] [9]. Piperine has also been known to inhibit CYP3A4 and P-glycoprotein due to which it has been used to enhance the bioavailability of other drugs [10]. When co-administered with curcumin, piperine increased the bioavailability of curcumin by 2000% [11]. In a clinical study, simultaneous…

Piperine is an alkaloid extracted from black pepper (P. nigrum) and long pepper (P. longum). Previous studies have shown that piperine has anti-inflammatory, antiarthritic and anti-depressant effects [8] [9]. Piperine has also been known to inhibit CYP3A4 and P-glycoprotein due to which it has been used to enhance the bioavailability of other drugs [10]. When co-administered with curcumin, piperine increased the bioavailability of curcumin by 2000% [11]. In a clinical study, simultaneous…

How Splenda makes you fat. Splenda reduces the amount of good bacteria in the intestines by 50%, increases the pH level in the intestines, contributes to increases in body weight and affects the P-glycoprotein (P-gp) in the body in such a way that crucial health-related drugs could be rejected"  How much Splenda caused this? It was the equivalent of 7 packets. Over time and daily use this could have extreme consequences’ on ones health and weight.

How Splenda makes you fat. Splenda reduces the amount of good bacteria in the intestines by 50%, increases the pH level in the intestines, contributes to increases in body weight and affects the P-glycoprotein (P-gp) in the body in such a way that crucial health-related drugs could be rejected" How much Splenda caused this? It was the equivalent of 7 packets. Over time and daily use this could have extreme consequences’ on ones health and weight.

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