The zebra stripe sign occurs where children with osteogenesis imperfecta have been treated with cyclical bisphosphonate therapy, e.g. pamidronate. When the drug is delivered in cycles, dense bone is formed while treatment is being given. This results in dense stripes across the metaphyses of bones which can be visualized radiographically.
For #invisibleillness awareness month here is some facts on osteogenesis imperfecta you might like to use to help spread the word! You can use the link from our website to read up more on OI: http://hypermobility.org/help-advice/osteogenesis-imperfecta-2/