Autoimmune Encephalitis: The Brain Disease That Makes People Seem Crazy | Violent outbursts, paranoia, psychosis, memory loss, speech problems, seizures, involuntary movements—it may be anti-NMDA receptor encephalitis...
"Anti-NMDA (N-methyl D-aspartate) receptor encephalitis is an acute form of encephalitis, potentially lethal but with high probability for recovery, caused by autoimmune reaction against NR1- and NR2-subunits of the glutamate NMDA receptor. Different descriptions and syndromal designations for this disease existed in the medical literature prior to 2007, when the cause was established and it received its current name."
Wind-up pain is caused by activation of normally dormant NMDA receptors.Activated NMDA receptors cause - influx of Calcium into Dorsal Horn Wide Dynamic Range interneurons resulting in a cycle of - increased production/sensitization/number of NMDA receptors & increased release of Glutamate/Substance-P at presynaptic sites This positive feedback loop results in a marked increase in the pain signal ultimately perceived by the brain.
Ketamine is a drug used in human and veterinary medicine, primarily for the induction and maintenance of general anesthesia, usually in combination with a sedative. Pharmacologically, ketamine is classified as an NMDA receptor antagonist.