There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in primates like humans. However, adolescent cynomolgus monkeys that were injected daily for six months with the non-competitive NMDA antagonist ketamine showed decreased locomotor activity and increased apoptosis of cells in their prefrontal cortices.

There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in primates like humans. However, adolescent cynomolgus monkeys that were injected daily for six months with the non-competitive NMDA antagonist ketamine showed decreased locomotor activity and increased apoptosis of cells in their prefrontal cortices.

NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-methyl d-aspartate receptor (NMDAR). They are used as anesthesia for animals and, less commonly, for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Memantine is an uncompetitive NMDA channel blocker. Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA glutamate…

NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-methyl d-aspartate receptor (NMDAR). They are used as anesthesia for animals and, less commonly, for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Memantine is an uncompetitive NMDA channel blocker. Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA glutamate…

Alomone Labs D-AP5, a competitive NMDA receptor antagonist.

Alomone Labs D-AP5, a competitive NMDA receptor antagonist.

Phencyclidine (a complex clip of the chemical name 1-(1-phenylcyclohexyl)piperidine), (PCP) and known colloquially as angel dust or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits both hallucinogenic and neurotoxic effects. PCP is an NMDA receptor antagonist.PCP is an NMDA receptor antagonist. PCP, like ketamine, also acts as a D2 receptor partial agonist. D2 receptor antagonists (such as haloperidol) can be used in the treatment of PCP psychosis.

Phencyclidine (a complex clip of the chemical name 1-(1-phenylcyclohexyl)piperidine), (PCP) and known colloquially as angel dust or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits both hallucinogenic and neurotoxic effects. PCP is an NMDA receptor antagonist.PCP is an NMDA receptor antagonist. PCP, like ketamine, also acts as a D2 receptor partial agonist. D2 receptor antagonists (such as haloperidol) can be used in the treatment of PCP psychosis.

NMDA receptor antagonist ... Can be used to treat resistant forms of Catatonia

NMDA receptor antagonist ... Can be used to treat resistant forms of Catatonia

Ketamine is a drug used in human and veterinary medicine, primarily for the induction and maintenance of general anesthesia, usually in combination with a sedative.  Pharmacologically, ketamine is classified as an NMDA receptor antagonist.

Ketamine is a drug used in human and veterinary medicine, primarily for the induction and maintenance of general anesthesia, usually in combination with a sedative. Pharmacologically, ketamine is classified as an NMDA receptor antagonist.

Stopping anti-clotting medications in some patients with irregular heartbeats may raise the risk of stroke or blood clotting within a month, finds a new research.

Stopping anti-clotting medications in some patients with irregular heartbeats may raise the risk of stroke or blood clotting within a month, finds a new research.

Memantine is approved for the treatment of moderate to severe  Alzheimer’s. It is an N-methyl-D-aspartate (NMDA) receptor antagonist.  The NMDA receptor is one of several receptors located on  the postsynaptic neurons in the hippocampus, which receive  transmissions from the neurotransmitter glutamate. Glutamate is a major excitatory neurotransmitter that is associated  with learning and memory, used by more than 80% of the neurons  in the brain.

Memantine is approved for the treatment of moderate to severe Alzheimer’s. It is an N-methyl-D-aspartate (NMDA) receptor antagonist. The NMDA receptor is one of several receptors located on the postsynaptic neurons in the hippocampus, which receive transmissions from the neurotransmitter glutamate. Glutamate is a major excitatory neurotransmitter that is associated with learning and memory, used by more than 80% of the neurons in the brain.

DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative…

DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative…

Pinterest • The world’s catalogue of ideas
Search