The Winchester Brothers, Supernatural These brothers have been to hell and back — literally. It's up for debate whether Sam (Jared Padalecki) and Dean (Jensen Ackles) are each other's greatest weakness or greatest strength, but they are both without a doubt unceasingly (and endearingly) protective of one another. Bonus points for keeping a sense of humor while saving the world. —Emily Rome
Jared Padalecki Photos Photos: Jensen Ackles and Jared Padalecki on Set for "Supernatural"