Raphael's Marriage of the Virgin, 1504. Geometric perspective, serene faces (except for the rejected suitor breaking his staff), passionate (if a little monotone) colors. A celebration of the Church, the Renaissance and (he signed his name!) the artist himself.
The Creation of Adam (c.1511). God passing the Spark of Life to Adam. One of the most famous images of High Renaissance Christian art, it is part of the Genesis fresco (1512) on the ceiling of the Sistine Chapel in Rome.