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Trastuzumab 180288-69-1 is used w/ chemotherapeutic drugs to treat HER2-positive advanced gastroesophageal junction cancer and is a promising new treatment option. HER2 protein is responsible for cell growth and division and the cell proliferation is regulated at different checkpoints. A defect in this protein may result in the uncontrolled proliferation of the cell resulting in a tumor.  Trastuzumab is a humanized mAb which help arrest the cell cycle at the G1 phase and hence the cell…

Trastuzumab 180288-69-1 is used w/ chemotherapeutic drugs to treat HER2-positive advanced gastroesophageal junction cancer and is a promising new treatment option. HER2 protein is responsible for cell growth and division and the cell proliferation is regulated at different checkpoints. A defect in this protein may result in the uncontrolled proliferation of the cell resulting in a tumor. Trastuzumab is a humanized mAb which help arrest the cell cycle at the G1 phase and hence the cell…

This interactive notebook cut-and-paste notes activity is designed to help students understand the concept of the cell cycle and mitosis. Topics covered include: G1 phase, G0 phase, S phase, G2 phase, and M phase (or cell division). Mitosis in-depth notes are found in another activity.

Interactice Notebook Cell Cycle Note Page

This interactive notebook cut-and-paste notes activity is designed to help students understand the concept of the cell cycle and mitosis. Topics covered include: G1 phase, G0 phase, S phase, G2 phase, and M phase (or cell division). Mitosis in-depth notes are found in another activity.

Figure 2. Assembly of pre-replication and pre-initiation protein complexes. The origin recognition complex (ORC) is a platform for the assembly of pre-replication complexes. In metazoans, chromatin-bound ORC recruits CDC6 and CDT1 in Telophase to G1-phase transition, facilitating the loading of a helicase complex consisting of MCM and resulting the pre-replication complex (PreRC). The PreRC is activated to create the pre-initiation complex (PreIC) by recruitment of additional factors ...

Figure 2. Assembly of pre-replication and pre-initiation protein complexes. The origin recognition complex (ORC) is a platform for the assembly of pre-replication complexes. In metazoans, chromatin-bound ORC recruits CDC6 and CDT1 in Telophase to G1-phase transition, facilitating the loading of a helicase complex consisting of MCM and resulting the pre-replication complex (PreRC). The PreRC is activated to create the pre-initiation complex (PreIC) by recruitment of additional factors ...

Figure 6: Histogram showing the effect of DKC1 siRNA on HCT116 cell cycle in the absence (A) or presence (B) of 5-FU. Cells were transfected with siRNA for 48 hand then cultured with or without the addition of 5-FU. (A) Knockdown of DKC1 significantly increased the percentage of HCT116 cells in G1 phase (P<0.05) when compared to control cells after 48 hours post-transfection. (B) 5-FU treatment following silencing of DKC1 arrested HCT116 cells in G2 phase when compared to the control…

Figure 6: Histogram showing the effect of DKC1 siRNA on HCT116 cell cycle in the absence (A) or presence (B) of 5-FU. Cells were transfected with siRNA for 48 hand then cultured with or without the addition of 5-FU. (A) Knockdown of DKC1 significantly increased the percentage of HCT116 cells in G1 phase (P<0.05) when compared to control cells after 48 hours post-transfection. (B) 5-FU treatment following silencing of DKC1 arrested HCT116 cells in G2 phase when compared to the control…

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G1 and G2: What Happens in the Growth Phases of The Cell Cycle?

G1 and G2: What Happens in the Growth Phases of The Cell Cycle?

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What Happens in the G1 and G2 Phases of The Cell Cycle? https://www.albert.io/blog/g1-g2-phases-cell-cycle/

What Happens in the G1 and G2 Phases of The Cell Cycle? https://www.albert.io/blog/g1-g2-phases-cell-cycle/

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Inhibition of the cell cycle by immunosuppressants.  Azathioprine, mycophenolate mofetil and methotrexate are relatively specific cell-cycle inhibitors, affecting mainly the resting and DNA synthesis phases. Cyclophosphamide is a nonspecific cell-cycle inhibitor and affects all phases. Abbreviations: AZA, azathioprine; CY, cyclophosphamide; G0, dormant phase; G1, resting phase; G2, premitotic phase; M, mitotic phase; MMF, mycophenolate mofetil; MTX, methotrexate; S, DNA synthesis phase.

Inhibition of the cell cycle by immunosuppressants. Azathioprine, mycophenolate mofetil and methotrexate are relatively specific cell-cycle inhibitors, affecting mainly the resting and DNA synthesis phases. Cyclophosphamide is a nonspecific cell-cycle inhibitor and affects all phases. Abbreviations: AZA, azathioprine; CY, cyclophosphamide; G0, dormant phase; G1, resting phase; G2, premitotic phase; M, mitotic phase; MMF, mycophenolate mofetil; MTX, methotrexate; S, DNA synthesis phase.

Interphase & Meiosis are different phases of cell Division. Meiosis is the 2nd part of cell division. The 1st is a period of growth called interphase including: G1 (1st gap) phase-the cell increases in mass in preparation for cell division.  S(ynthesis) phase: The period during which DNA is duplicated. G2 phase- DNA checkpoint prior to the start of prophase, synthesizes proteins and continues to increase in size. In the latter part of interphase, the cell still has nucleoli present.

Interphase & Meiosis are different phases of cell Division. Meiosis is the 2nd part of cell division. The 1st is a period of growth called interphase including: G1 (1st gap) phase-the cell increases in mass in preparation for cell division. S(ynthesis) phase: The period during which DNA is duplicated. G2 phase- DNA checkpoint prior to the start of prophase, synthesizes proteins and continues to increase in size. In the latter part of interphase, the cell still has nucleoli present.

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