National Guideline Clearinghouse | Chemotherapy and targeted therapy for women with human epidermal growth factor receptor 2–negative (or unknown) advanced breast cancer: American Society of Clinical Oncology clinical practice guideline.

National Guideline Clearinghouse | Chemotherapy and targeted therapy for women with human epidermal growth factor receptor 2–negative (or unknown) advanced breast cancer: American Society of Clinical Oncology clinical practice guideline.

Nearly a quarter of advanced lung cancer patients fail to receive epidermal growth factor receptor (EGFR) gene mutation test results before starting treatment, according to a new survey of oncologists in 10 countries.

Cancer Society's Retiring Chief Shares Parting Thoughts

Nearly a quarter of advanced lung cancer patients fail to receive epidermal growth factor receptor (EGFR) gene mutation test results before starting treatment, according to a new survey of oncologists in 10 countries.

Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor sign...

Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor sign...

Cancer and the Epidermal Growth Factor Receptor

Cancer and the Epidermal Growth Factor Receptor

Niclosamide inhibits epithelial-mesenchymal transition and tumor growth in lapatinib-resistant human epidermal growth factor receptor 2-positive breast cancer — ScienceDirect

Niclosamide inhibits epithelial-mesenchymal transition and tumor growth in lapatinib-resistant human epidermal growth factor receptor 2-positive breast cancer — ScienceDirect

Epidermal Growth Factor Receptor and Its Applications - The discovery of growth factors won the Nobel Prize in Medicine in 1986, implying their importance.  Epidermal growth factor receptor, EGFR, one of such factors, exists on cell surface and is activated by binding of its specific ligands.  EGFR is a member of the receptor tyrosine kinase family whose members play a critical role in oncogenesis. Mutations affecting EGFR expression or activity could result in cancers, ...

Epidermal Growth Factor Receptor and Its Applications - The discovery of growth factors won the Nobel Prize in Medicine in 1986, implying their importance. Epidermal growth factor receptor, EGFR, one of such factors, exists on cell surface and is activated by binding of its specific ligands. EGFR is a member of the receptor tyrosine kinase family whose members play a critical role in oncogenesis. Mutations affecting EGFR expression or activity could result in cancers, ...

Global Medical Discovery features paper: Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase

Global Medical Discovery features paper: Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase

This infographic shows the Breast Cancer Subtypes in Women.  It’s important for guiding treatment and predicting survival. Know the Science: HR = Hormone receptor. HR+ means tumor cells have receptors for the hormones estrogen or progesterone, which can promote the growth of HR+ tumors. Hormone therapies like tamoxifen can be used to treat HR+ tumors. HER2 = Human epidermal growth Factor receptor, HER2+ means tumor cells overexpress (make high levels of) a protein, called HE2/neu, which has…

This infographic shows the Breast Cancer Subtypes in Women. It’s important for guiding treatment and predicting survival. Know the Science: HR = Hormone receptor. HR+ means tumor cells have receptors for the hormones estrogen or progesterone, which can promote the growth of HR+ tumors. Hormone therapies like tamoxifen can be used to treat HR+ tumors. HER2 = Human epidermal growth Factor receptor, HER2+ means tumor cells overexpress (make high levels of) a protein, called HE2/neu, which has…

Recently, new drugs targeted at specific cancer cell mutations were produced. About 60% of glioblastoma cells have a mutated variant of the epidermal growth factor receptor (EGFRvIII) on their surface. This receptor, found in extrachromosomal DNA, plays a role in acceleration of cancer growth. EGFRvIII suppressors and inhibitors were used in glioblastoma therapy, however drug resistance developed very quickly.

Recently, new drugs targeted at specific cancer cell mutations were produced. About 60% of glioblastoma cells have a mutated variant of the epidermal growth factor receptor (EGFRvIII) on their surface. This receptor, found in extrachromosomal DNA, plays a role in acceleration of cancer growth. EGFRvIII suppressors and inhibitors were used in glioblastoma therapy, however drug resistance developed very quickly.

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