Shutter Speed, ISO, Aperture ... To be comfortable shooting manual you will need to know what your necessary adjustments are. Though these settings are all numeric, there isnt some insane math equation that you need to do to find out what to dial them i
Portrait Lighting Setup poster to be helpful. It contains 24 different portrait lighting setups using a variety of lighting gear and lighting patterns. Click the image to see it up large. Also check out some of the further reading.