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Depression is not likely caused by unbalanced brain chemicals; however, there are a number of other biological factors that appear to be highly significant. http://articles.mercola.com/sites/articles/archive/2015/01/22/depression-causes.aspx

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Social Anxiety # 949 | Feeling embarrassed that you have no life because you're too afraid to socialize. I am not sure if I am embarrassed about it, more I get anxious and frustrated and depressed about it.

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Depression Screening Test | Psych Central

What Depression Screening Tests May Miss