Anissa Jones "Buffy" in the television show Family Affair. She died from combined drug intoxication at the age of 18.

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Combined or Mixed-Drug Intoxication: What Is It? | Combined drug intoxication is claiming an increasing number of lives. What is this phenomenon that killed Anna Nicole Smith, Heath Ledger and Whitney Houston?.

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Mary Anissa Jones (March 11, 1958 – August 28, 1976) was an American child actress known for her role as Buffy on the CBS sitcom Family Affair. She died from combined drug intoxication at the age of 18.

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John Belushi (1949–1982) was an American comedian, actor, & musician. He is best known for his "intense energy & raucous attitude" which he displayed as one of the original cast members of the NBC sketch comedy show Saturday Night Live, in his role in the 1978 film Animal House & in his recordings & performances as one of The Blues Brothers. Belushi died at the age of 33, after being injected with a mixture of cocaine & heroin, known as a "speedball", which led to combined drug intoxication.

PHILIP SEYMOUR HOFFMAN Actor Philip Seymour Hoffman was found dead in his Manhatten apartment on February 2, 2014. He had died from combined drug intoxication at age 46.RIP: Celebrities who died too soon

CDI is an unnatural cause of death where the person died from mixing various drugs and alcohol together. Combined Drug Intoxication used to be a rare occurrence, but has recently been on the rise.

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Anissa Jones Born 03-11-1958 Died: 08-28-1976 (Accidental Overdose - Her fatal overdose was of a combination of cocaine, angel dust, Quaaludes and Seconal. The San Diego County coroner said it was one of the most severe cases of drug overdose ever seen in San Diego County.) TELEVISION Family Affair Buffy Patterson-Davis (1966-71)

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Anissa Jones -- (1958-1976) Child Actress. She played Buffy on "Family Affair" . She passed away from combined drug intoxication

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River Phoenix last photo shoot - On October 31, 1993, Phoenix collapsed and died of combined drug intoxication on the sidewalk outside the West Hollywood nightclub The Viper Room at the age of 23.

Philip Seymour Hoffman (1967-2014) was an American actor,director,and producer. He was prolific in both film and theater from the early 1990's until his death,after which "The New York Times" declared him "perhaps the most ambitious and widely admired American actor of his generation". Hoffman died of combined drug intoxication in February 2014 (aged 46) in New York City.

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