Tuberculosis-primary infection; bacillus first enters body, macrophages engulf microbe causing local inflammatory response, some bacilli travel to lymph nodes (activate type IV hypersensitivity reaction); granuloma and tubercle forms, caseous necrosis and Ghon complexes develop, bacilli can remain dormant for years while remaining asymptomatic, but the person will test positive now.
Other Names: Sarcoid, Besnier-Boeck disease Sarcoidosis is chronic multi-systen autoimmune disease that causes abnormal cells to collect and form nodules, also known as Granulomas, throughout organs in the body. The most commonly affected are the lungs and lymph nodes, but can affect any organ or tissue within the body. The nodule inflammations can cause complications such as lung damage and interstitial lung disease, eye damage, kidney damage, heart damage,
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Wegner's granulomatosis is an uncommon disease, in this the blood vessels are inflamed (vasculitis). This inflammation damages important organs of the body by limiting blood flow to those organs and destroying normal tissue.