The story begins in an Australian lab in 1949 when John Cade had a hunch that urea would be effective in the treatment of bipolar disorder. He needed an agent to help the substance dissolve in water, which turned out to be the common salt lithium. He quickly found the solution had a calming affect on guinea pigs, but further experimentation showed that it was the lithium and not the urea that was the active ingredient. He then tried the agent on human subjects, with eye-popping results.
My Experience Losing Weight On Bipolar Meds | International Bipolar Foundation