Novel cyclic mini-β-defensin

Abstract: We have designed a cyclic 17-amino acid β-defensin analog featuring a single disulfide bond. Read this original research and sign up to receive International Journal of Nanomedicine here: https://www.dovepress.com/articles.php?article_id=24172
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Figure 1 Solution structure of AMC in H2O/D2O (90/10) (A–D) and in TFE/H2O (80/20) (E, F).

Figure 1 Solution structure of AMC in H2O/D2O (90/10) (A–D) and in TFE/H2O (80/20) (E, F).

Figure 2 hBD1 (pdb code 1KJ5), AMC, and hBD3 (pdb code1KJ6) solution structures are shown on the left, in the middle, and on the right, respectively.

Figure 2 hBD1 (pdb code 1KJ5), AMC, and hBD3 (pdb code1KJ6) solution structures are shown on the left, in the middle, and on the right, respectively.

Figure 6 Growth curves of Pseudomonas aeruginosa, Escherichia coli, and Enterococcus faecalis incubated with 2.5 μM AMC (gray bar) and in Ctr (black bar).

Figure 6 Growth curves of Pseudomonas aeruginosa, Escherichia coli, and Enterococcus faecalis incubated with 2.5 μM AMC (gray bar) and in Ctr (black bar).

Figure 3 Cytotoxicity of wild-type hBD1, hBD3 and AMC.

Figure 3 Cytotoxicity of wild-type hBD1, hBD3 and AMC.

Figure 4 Antibacterial activity of wild-type hBD1, hBD3 and AMC also in the presence of NaCl.

Figure 4 Antibacterial activity of wild-type hBD1, hBD3 and AMC also in the presence of NaCl.

Figure 5 Antibacterial activity of wild-type hBD1, hBD3 and AMC also in presence of Ca2+ and Mg2+.

Figure 5 Antibacterial activity of wild-type hBD1, hBD3 and AMC also in presence of Ca2+ and Mg2+.

Figure 8 Time-course of the incubation of oxidized AMC in human serum.

Figure 8 Time-course of the incubation of oxidized AMC in human serum.

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