Multicomponent reactions for small-molecule libraries

Abstract: The current drug discovery process is dependent on the ability of synthetic chemistry to deliver libraries of small molecules with ever increasing levels of structural complexity and diversity. Read this review and sign up to receive Reports in Organic Chemistry journal here: https://www.dovepress.com/articles.php?article_id=23532
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Figure 2 Naturally occurring compounds, synthetic drugs, or bioactive compounds with core structures identical or closely related to the products of the MCRs described herein.

Figure 2 Naturally occurring compounds, synthetic drugs, or bioactive compounds with core structures identical or closely related to the products of the MCRs described herein.

Figure 8 Transition metal-catalyzed MCRs in sequential protocols (part 1).

Figure 8 Transition metal-catalyzed MCRs in sequential protocols (part 1).

Figure 5 Isocyanide-based MCRs in sequential protocols (part 1).

Figure 5 Isocyanide-based MCRs in sequential protocols (part 1).

Figure 9 Transition metal-catalyzed MCRs in sequential protocols (part 2).

Figure 9 Transition metal-catalyzed MCRs in sequential protocols (part 2).

Figure 1 Overview of sequential MCR/elaboration, tandem MCR/cyclization, and MCR2 strategies for the generation of diversity.

Figure 1 Overview of sequential MCR/elaboration, tandem MCR/cyclization, and MCR2 strategies for the generation of diversity.

Figure 3 Classical carbonyl condensations-based MCRs in sequential protocols (part 1).

Figure 3 Classical carbonyl condensations-based MCRs in sequential protocols (part 1).

Figure 4 Classical carbonyl condensations-based MCRs in sequential protocols (part 2).

Figure 4 Classical carbonyl condensations-based MCRs in sequential protocols (part 2).

Figure 6 Isocyanide-based MCRs in sequential protocols (part 2).

Figure 6 Isocyanide-based MCRs in sequential protocols (part 2).

Figure 7 Cycloaddition-based MCRs in sequential protocols.

Figure 7 Cycloaddition-based MCRs in sequential protocols.

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