Dual pH/time-dependent nanoparticles for colitis therapy

Abstract: Single pH-dependent drug delivery systems have been widely used for colon-targeted delivery, but their efficiency is often hampered by the variation in gut pH. Read this original research and sign up to receive Drug Design, Development and Therapy journal here: http://www.dovepress.com/articles.php?article_id=22718
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Figure 9 Proposed mechanism of budesonide release and colon-targeting of the single-systems (pH–NPs and Time_NPs) and dual-system (pH/Time_NPs) under GI tract mimicking conditions.

Figure 9 Proposed mechanism of budesonide release and colon-targeting of the single-systems (pH–NPs and Time_NPs) and dual-system (pH/Time_NPs) under GI tract mimicking conditions.

Figure 1 Schematic illustration of NPs preparation.

Figure 1 Schematic illustration of NPs preparation.

Figure 2 Morphology and size distribution of NPs.

Figure 2 Morphology and size distribution of NPs.

Figure 3 In vitro drug release profiles of NPs.

Figure 3 In vitro drug release profiles of NPs.

Figure 4 In vivo distribution of NPs in mice gastrointestinal tract.

Figure 4 In vivo distribution of NPs in mice gastrointestinal tract.

Figure 5 DAI and body weight changes of healthy, untreated, and NPs-treated groups during the whole experimental period.

Figure 5 DAI and body weight changes of healthy, untreated, and NPs-treated groups during the whole experimental period.

Figure 6 Macroscopic evaluation of colitis.

Figure 6 Macroscopic evaluation of colitis.

Figure 7 Histological evaluation of colitis.

Figure 7 Histological evaluation of colitis.

Figure 8 Immunostaining of colon cryosections.

Figure 8 Immunostaining of colon cryosections.

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